KEGG   Homo sapiens (human): 11035
Entry
11035             CDS       T01001                                 
Symbol
RIPK3, RIP3
Name
(RefSeq) receptor interacting serine/threonine kinase 3
  KO
K08847  receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04217  Necroptosis
hsa04621  NOD-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa04668  TNF signaling pathway
hsa05132  Salmonella infection
Network
nt06516  TNF signaling
nt06527  Necroptosis
  Element
N01583  Regulation of extrinsic apoptotic pathway, XIAP
N01621  TNF-RIPK1/3 signaling pathway
N01625  CYLD regulation of RIPK1/3
N01631  TNFSF10-RIPK1/3 signaling pathway
N01632  FASLG-RIPK1/3 signaling pathway
N01633  TLR3-RIPK3 signaling pathway
N01634  TLR4-RIPK3 signaling pathway
N01650  SQSTM1 regulation of RIPK1/3
N01662  IFN-RIPK1/3 signaling pathway
N01663  CASP8 regulation of RIPK1/3
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    11035 (RIPK3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    11035 (RIPK3)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    11035 (RIPK3)
   04623 Cytosolic DNA-sensing pathway
    11035 (RIPK3)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    11035 (RIPK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    11035 (RIPK3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     11035 (RIPK3)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: TKL group
  RIPK family [OT]
   11035 (RIPK3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RHIM APH ABC1 TrbM
Other DBs
NCBI-GeneID: 11035
NCBI-ProteinID: NP_006862
OMIM: 605817
HGNC: 10021
Ensembl: ENSG00000129465
UniProt: Q9Y572
Structure
Position
14:complement(24336025..24339991)
AA seq 518 aa
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
NT seq 1557 nt   +upstreamnt  +downstreamnt
atgtcgtgcgtcaagttatggcccagcggtgcccccgcccccttggtgtccatcgaggaa
ctggagaaccaggagctcgtcggcaaaggcgggttcggcacagtgttccgggcgcaacat
aggaagtggggctacgatgtggcggtcaagatcgtaaactcgaaggcgatatccagggag
gtcaaggccatggcaagtctggataacgaattcgtgctgcgcctagaaggggttatcgag
aaggtgaactgggaccaagatcccaagccggctctggtgactaaattcatggagaacggc
tccttgtcggggctgctgcagtcccagtgccctcggccctggccgctcctttgccgcctg
ctgaaagaagtggtgcttgggatgttttacctgcacgaccagaacccggtgctcctgcac
cgggacctcaagccatccaacgtcctgctggacccagagctgcacgtcaagctggcagat
tttggcctgtccacatttcagggaggctcacagtcagggacagggtccggggagccaggg
ggcaccctgggctacttggccccagaactgtttgttaacgtaaaccggaaggcctccaca
gccagtgacgtctacagcttcgggatcctaatgtgggcagtgcttgctggaagagaagtt
gagttgccaaccgaaccatcactcgtgtacgaagcagtgtgcaacaggcagaaccggcct
tcattggctgagctgccccaagccgggcctgagactcccggcttagaaggactgaaggag
ctaatgcagctctgctggagcagtgagcccaaggacagaccctccttccaggaatgccta
ccaaaaactgatgaagtcttccagatggtggagaacaatatgaatgctgctgtctccacg
gtaaaggatttcctgtctcagctcaggagcagcaataggagattttctatcccagagtca
ggccaaggagggacagaaatggatggctttaggagaaccatagaaaaccagcactctcgt
aatgatgtcatggtttctgagtggctaaacaaactgaatctagaggagcctcccagctct
gttcctaaaaaatgcccgagccttaccaagaggagcagggcacaagaggagcaggttcca
caagcctggacagcaggcacatcttcagattcgatggcccaacctccccagactccagag
acctcaactttcagaaaccagatgcccagccctacctcaactggaacaccaagtcctgga
ccccgagggaatcagggggctgagagacaaggcatgaactggtcctgcaggaccccggag
ccaaatccagtaacagggcgaccgctcgttaacatatacaactgctctggggtgcaagtt
ggagacaacaactacttgactatgcaacagacaactgccttgcccacatggggcttggca
ccttcgggcaaggggaggggcttgcagcaccccccaccagtaggttcgcaagaaggccct
aaagatcctgaagcctggagcaggccacagggttggtataatcatagcgggaaataa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (12)   
   KEGG NETWORK (12)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
3D Structure (6)   
   PDB (6)   
Protein domain (6)   
   Pfam (6)   
All databases (86)   

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